diff --git a/CMakeLists.txt b/CMakeLists.txt
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -19,7 +19,10 @@ if("${LOWERCASE_BUILD_TYPE}" STREQUAL "debug")
     set(DEBUG TRUE)
 endif()
 include(TestBigEndian)
-test_big_endian(WORDS_BIGENDIAN)
+string(TOLOWER ${CMAKE_SYSTEM_NAME} SYSTEM_LOWER)
+if(NOT SYSTEM_LOWER STREQUAL "emscripten")
+    test_big_endian(WORDS_BIGENDIAN)
+endif()
 include(CheckIncludeFiles)
 check_include_files("stdlib.h;stdio.h;stdarg.h;string.h;float.h;limits.h;math.h" STDC_HEADERS)
 set(HAVE_STDLIB_H ${STDC_HEADERS} CACHE INTERNAL "Have include stdlib.h")