diff --git a/CMakeLists.txt b/CMakeLists.txt
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -25,10 +25,6 @@ set(PHYSFS_CPP_SRCS)
 
 # I hate that they define "WIN32" ... we're about to move to Win64...I hope!
 
-if(APPLE)
-    set(OTHER_LDFLAGS ${OTHER_LDFLAGS} "-framework IOKit -framework Foundation")
-    list(APPEND PHYSFS_M_SRCS src/physfs_platform_apple.m)
-endif()
 
 if(CMAKE_COMPILER_IS_GNUCC OR CMAKE_C_COMPILER_ID MATCHES "Clang")
     add_compile_options(-Wall)
@@ -58,7 +54,7 @@ if(WINRT)
     list(APPEND PHYSFS_CPP_SRCS src/physfs_platform_winrt.cpp)
 endif()
 
-if(UNIX AND NOT WIN32 AND NOT APPLE)  # (MingW and such might be UNIX _and_ WINDOWS!)
+if(UNIX AND NOT WIN32)  # (MingW and such might be UNIX _and_ WINDOWS!)
     find_library(PTHREAD_LIBRARY pthread)
     if(PTHREAD_LIBRARY)
         set(OPTIONAL_LIBRARY_LIBS ${OPTIONAL_LIBRARY_LIBS} ${PTHREAD_LIBRARY})
@@ -172,11 +168,20 @@ if(PHYSFS_BUILD_STATIC)
 		set_target_properties(physfs-static PROPERTIES VS_WINRT_COMPONENT True)
         set_target_properties(physfs-static PROPERTIES STATIC_LIBRARY_FLAGS "/ignore:4264")
     endif()
+    set(CPP_DEFS)
+    set(INC_PATHS)
+    include(CheckSymbolExists)
+    check_symbol_exists(__DEVKITPPC__ "sys/config.h" DEVKITPPC)
+    if(DEVKITPPC)
+        set(CPP_DEFS ${CPP_DEFS} MKXPZ_DEVKITPPC)
+        set(INC_PATHS ${INC_PATHS} "$ENV{DEVKITPRO}/libogc/include")
+    endif()
     if(WIN32 OR WINRT OR OS2)
         # no dll exports from the static library
-        target_compile_definitions(physfs-static PRIVATE "PHYSFS_STATIC")
+        set(CPP_DEFS ${CPP_DEFS} "PHYSFS_STATIC")
     endif()
-    target_include_directories(physfs-static PUBLIC "$<BUILD_INTERFACE:${CMAKE_CURRENT_SOURCE_DIR}/src>")
+    target_compile_definitions(physfs-static PRIVATE ${CPP_DEFS})
+    target_include_directories(physfs-static PUBLIC "$<BUILD_INTERFACE:${CMAKE_CURRENT_SOURCE_DIR}/src>" ${INC_PATHS})
     target_link_libraries(physfs-static PRIVATE ${OPTIONAL_LIBRARY_LIBS} ${OTHER_LDFLAGS})
     set(PHYSFS_LIB_TARGET physfs-static)
     list(APPEND PHYSFS_INSTALL_TARGETS "physfs-static")
diff --git a/src/physfs_platform_posix.c b/src/physfs_platform_posix.c
--- a/src/physfs_platform_posix.c
+++ b/src/physfs_platform_posix.c
@@ -19,7 +19,11 @@
 #include <dirent.h>
 #include <errno.h>
 #include <fcntl.h>
-#include <pthread.h>
+#ifdef MKXPZ_DEVKITPPC
+#  include <ogc/mutex.h>
+#else
+#  include <pthread.h>
+#endif
 
 #include "physfs_internal.h"
 
@@ -369,15 +373,23 @@ int __PHYSFS_platformStat(const char *fname, PHYSFS_Stat *st, const int follow)
 
 typedef struct
 {
+#ifdef MKXPZ_DEVKITPPC
+    mutex_t mutex;
+#else
     pthread_mutex_t mutex;
     pthread_t owner;
+#endif
     PHYSFS_uint32 count;
 } PthreadMutex;
 
 
 void *__PHYSFS_platformGetThreadID(void)
 {
+#ifdef MKXPZ_DEVKITPPC
+    return (void *)42;
+#else
     return ( (void *) ((size_t) pthread_self()) );
+#endif
 } /* __PHYSFS_platformGetThreadID */
 
 
@@ -386,7 +398,11 @@ void *__PHYSFS_platformCreateMutex(void)
     int rc;
     PthreadMutex *m = (PthreadMutex *) allocator.Malloc(sizeof (PthreadMutex));
     BAIL_IF(!m, PHYSFS_ERR_OUT_OF_MEMORY, NULL);
+#ifdef MKXPZ_DEVKITPPC
+    rc = LWP_MutexInit(&m->mutex, false);
+#else
     rc = pthread_mutex_init(&m->mutex, NULL);
+#endif
     if (rc != 0)
     {
         allocator.Free(m);
@@ -394,7 +410,9 @@ void *__PHYSFS_platformCreateMutex(void)
     } /* if */
 
     m->count = 0;
+#ifndef MKXPZ_DEVKITPPC
     m->owner = (pthread_t) 0xDEADBEEF;
+#endif
     return ((void *) m);
 } /* __PHYSFS_platformCreateMutex */
 
@@ -403,11 +421,15 @@ void __PHYSFS_platformDestroyMutex(void *mutex)
 {
     PthreadMutex *m = (PthreadMutex *) mutex;
 
+#ifdef MKXPZ_DEVKITPPC
+    LWP_MutexDestroy(m->mutex);
+#else
     /* Destroying a locked mutex is a bug, but we'll try to be helpful. */
     if ((m->owner == pthread_self()) && (m->count > 0))
         pthread_mutex_unlock(&m->mutex);
 
     pthread_mutex_destroy(&m->mutex);
+#endif
     allocator.Free(m);
 } /* __PHYSFS_platformDestroyMutex */
 
@@ -415,6 +437,10 @@ void __PHYSFS_platformDestroyMutex(void *mutex)
 int __PHYSFS_platformGrabMutex(void *mutex)
 {
     PthreadMutex *m = (PthreadMutex *) mutex;
+#ifdef MKXPZ_DEVKITPPC
+    if (LWP_MutexLock(m->mutex) != 0)
+        return 0;
+#else
     pthread_t tid = pthread_self();
     if (m->owner != tid)
     {
@@ -422,6 +448,7 @@ int __PHYSFS_platformGrabMutex(void *mutex)
             return 0;
         m->owner = tid;
     } /* if */
+#endif
 
     m->count++;
     return 1;
@@ -431,6 +458,9 @@ int __PHYSFS_platformGrabMutex(void *mutex)
 void __PHYSFS_platformReleaseMutex(void *mutex)
 {
     PthreadMutex *m = (PthreadMutex *) mutex;
+#ifdef MKXPZ_DEVKITPPC
+    LWP_MutexUnlock(m->mutex);
+#else
     assert(m->owner == pthread_self());  /* catch programming errors. */
     assert(m->count > 0);  /* catch programming errors. */
     if (m->owner == pthread_self())
@@ -441,6 +471,7 @@ void __PHYSFS_platformReleaseMutex(void *mutex)
             pthread_mutex_unlock(&m->mutex);
         } /* if */
     } /* if */
+#endif
 } /* __PHYSFS_platformReleaseMutex */
 
 #endif  /* PHYSFS_PLATFORM_POSIX */
diff --git a/src/physfs_platforms.h b/src/physfs_platforms.h
--- a/src/physfs_platforms.h
+++ b/src/physfs_platforms.h
@@ -31,13 +31,9 @@
 #elif defined(__OS2__) || defined(OS2)
 #  define PHYSFS_PLATFORM_OS2 1
 #elif ((defined __MACH__) && (defined __APPLE__))
-/* To check if iOS or not, we need to include this file */
-#  include <TargetConditionals.h>
-#  if ((TARGET_IPHONE_SIMULATOR) || (TARGET_OS_IPHONE))
-#     define PHYSFS_NO_CDROM_SUPPORT 1
-#  endif
-#  define PHYSFS_PLATFORM_APPLE 1
+#  define PHYSFS_PLATFORM_UNIX 1
 #  define PHYSFS_PLATFORM_POSIX 1
+#  define PHYSFS_NO_CDROM_SUPPORT 1
 #elif defined(macintosh)
 #  error Classic Mac OS support was dropped from PhysicsFS 2.0. Move to OS X.
 #elif defined(__ANDROID__)
@@ -73,7 +69,10 @@
 #  define PHYSFS_PLATFORM_UNIX 1
 #  define PHYSFS_PLATFORM_POSIX 1
 #else
-#  error Unknown platform.
+#  warning Unknown platform.
+#  define PHYSFS_PLATFORM_UNIX 1
+#  define PHYSFS_PLATFORM_POSIX 1
+#  define PHYSFS_NO_CDROM_SUPPORT 1
 #endif
 
 #endif  /* include-once blocker. */